4KML
Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody
Summary for 4KML
Entry DOI | 10.2210/pdb4kml/pdb |
Related | 4N9O |
Descriptor | Major prion protein, Nanobody (3 entities in total) |
Functional Keywords | prion-like fold, antibody, nanobody, membrane protein-protein binding complex, membrane protein/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Lipid-anchor, GPI-anchor . Isoform 2: Cytoplasm : P04156 |
Total number of polymer chains | 2 |
Total formula weight | 40478.66 |
Authors | Abskharon, R.N.N.,Giachin, G.,Wohlkonig, A.,Soror, S.H.,Pardon, E.,Legname, G.,Steyaert, J. (deposition date: 2013-05-08, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Abskharon, R.N.,Giachin, G.,Wohlkonig, A.,Soror, S.H.,Pardon, E.,Legname, G.,Steyaert, J. Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody. J.Am.Chem.Soc., 136:937-944, 2014 Cited by PubMed: 24400836DOI: 10.1021/ja407527p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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