4KML

Probing the N-terminal beta-sheet conversion in the crystal structure of the full-length human prion protein bound to a Nanobody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Major prion protein	polymer	241	26201.9	1	UniProt (P04156) Pfam (PF00377) In PDB	Homo sapiens (human)	PrP, ASCR, PrP27-30, PrP33-35C
2	B	Nanobody	polymer	130	14276.8	1		Lama glama (llama)
3		water	water		18.0	89	Chemie (HOH)

Sequence modifications

A: 24 - 231 (UniProt: P04156)

PDB	External Database	Details
Met -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Pro 6	-	expression tag
Arg 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
His 10	-	expression tag
Met 11	-	expression tag
Ala 12	-	expression tag
Ser 13	-	expression tag
Met 14	-	expression tag
Thr 15	-	expression tag
Gly 16	-	expression tag
Gly 17	-	expression tag
Gln 18	-	expression tag
Gln 19	-	expression tag
Met 20	-	expression tag
Gly 21	-	expression tag
Arg 22	-	expression tag
Gly 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40478.7
All*	Total formula weight	40478.7

*Water molecules are not included.