4KI5

Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99

Summary for 4KI5

• Entry DOI: 10.2210/pdb4ki5/pdb
• Descriptor: MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, MURINE MONOCLONAL G99 FAB HEAVY CHAIN, ... (6 entities in total)
• Functional Keywords: immunoglobulin fold, discoidin fold, antibody, blood coagulation factor, antigen binding, blood plasma, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00451
• Total number of polymer chains: 5
• Total formula weight: 115198.31

Authors

Walter, J.D.,Meeks, S.L.,Healey, J.F.,Lollar, P.,Spiegel, P.C. (deposition date: 2013-05-01, release date: 2014-01-15)

• Primary citation: Walter, J.D.,Werther, R.A.,Brison, C.M.,Cragerud, R.K.,Healey, J.F.,Meeks, S.L.,Lollar, P.,Spiegel, P.C.; Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.; Blood, 122:4270-4278, 2013; PubMed: 24085769; DOI: 10.1182/blood-2013-08-519124

Experimental method

X-RAY DIFFRACTION (2.47 Å)