4KI5

Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN	polymer	219	23538.4	1		Mus musculus
2	B (D)	MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN	polymer	213	23330.8	1		Mus musculus
3	C (E)	MURINE MONOCLONAL G99 FAB HEAVY CHAIN	polymer	224	23952.6	1		Mus musculus
4	D (F)	MURINE MONOCLONAL G99 FAB LIGHT CHAIN	polymer	214	23640.0	1		Mus musculus
5	E (M)	Coagulation factor VIII	polymer	183	20736.6	1	UniProt (P00451) Pfam (PF00754)	Homo sapiens (human)	Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain
6	F, G, H, I, J (C, D, E, F, M)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

M: 2171 - 2332 (UniProt: P00451)

PDB	External Database	Details
Met 2150	-	expression tag
Gly 2151	-	expression tag
Ser 2152	-	expression tag
Ser 2153	-	expression tag
His 2154	-	expression tag
His 2155	-	expression tag
His 2156	-	expression tag
His 2157	-	expression tag
His 2158	-	expression tag
His 2159	-	expression tag
Ser 2160	-	expression tag
Ser 2161	-	expression tag
Gly 2162	-	expression tag
Leu 2163	-	expression tag
Val 2164	-	expression tag
Pro 2165	-	expression tag
Arg 2166	-	expression tag
Gly 2167	-	expression tag
Ser 2168	-	expression tag
His 2169	-	expression tag
Met 2170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	115198.3
All*	Total formula weight	115198.3

*Water molecules are not included.