4KFQ
Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with 1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one
Summary for 4KFQ
Entry DOI | 10.2210/pdb4kfq/pdb |
Related | 1PB7 1PB8 1PB9 1PBQ |
Descriptor | Glutamate receptor ionotropic, NMDA 1, 1-sulfanyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, GLYCEROL, ... (5 entities in total) |
Functional Keywords | membrane protein, ligand binding domain, ionotropic glutamate receptor |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P35439 |
Total number of polymer chains | 2 |
Total formula weight | 69542.73 |
Authors | Steffensen, T.B.,Tabrizi, F.M.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-04-27, release date: 2013-10-09, Last modification date: 2023-09-20) |
Primary citation | Kvist, T.,Steffensen, T.B.,Greenwood, J.R.,Mehrzad Tabrizi, F.,Hansen, K.B.,Gajhede, M.,Pickering, D.S.,Traynelis, S.F.,Kastrup, J.S.,Brauner-Osborne, H. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J.Biol.Chem., 288:33124-33135, 2013 Cited by PubMed: 24072709DOI: 10.1074/jbc.M113.480210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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