4KCG

Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor

Summary for 4KCG

• Entry DOI: 10.2210/pdb4kcg/pdb
• Descriptor: Deoxycytidine kinase, N-{2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: phosphoryl transfer, phosphorylation, deoxycytidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 2
• Total formula weight: 67260.94

Authors

Nomme, J.,Lavie, A. (deposition date: 2013-04-24, release date: 2014-03-12, Last modification date: 2023-09-20)

• Primary citation: Nathanson, D.A.,Armijo, A.L.,Tom, M.,Li, Z.,Dimitrova, E.,Austin, W.R.,Nomme, J.,Campbell, D.O.,Ta, L.,Le, T.M.,Lee, J.T.,Darvish, R.,Gordin, A.,Wei, L.,Liao, H.I.,Wilks, M.,Martin, C.,Sadeghi, S.,Murphy, J.M.,Boulos, N.,Phelps, M.E.,Faull, K.F.,Herschman, H.R.,Jung, M.E.,Czernin, J.,Lavie, A.,Radu, C.G.; Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.; J.Exp.Med., 211:473-486, 2014; PubMed: 24567448; DOI: 10.1084/jem.20131738

Experimental method

X-RAY DIFFRACTION (2.09 Å)