4KCG
Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor
Summary for 4KCG
Entry DOI | 10.2210/pdb4kcg/pdb |
Descriptor | Deoxycytidine kinase, N-{2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | phosphoryl transfer, phosphorylation, deoxycytidine, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 2 |
Total formula weight | 67260.94 |
Authors | |
Primary citation | Nathanson, D.A.,Armijo, A.L.,Tom, M.,Li, Z.,Dimitrova, E.,Austin, W.R.,Nomme, J.,Campbell, D.O.,Ta, L.,Le, T.M.,Lee, J.T.,Darvish, R.,Gordin, A.,Wei, L.,Liao, H.I.,Wilks, M.,Martin, C.,Sadeghi, S.,Murphy, J.M.,Boulos, N.,Phelps, M.E.,Faull, K.F.,Herschman, H.R.,Jung, M.E.,Czernin, J.,Lavie, A.,Radu, C.G. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J.Exp.Med., 211:473-486, 2014 Cited by PubMed: 24567448DOI: 10.1084/jem.20131738 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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