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4KCG

Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004136molecular_functiondeoxyadenosine kinase activity
A0004137molecular_functiondeoxycytidine kinase activity
A0004138molecular_functiondeoxyguanosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006139biological_processnucleobase-containing compound metabolic process
A0006220biological_processpyrimidine nucleotide metabolic process
A0008144molecular_functionobsolete drug binding
A0009224biological_processCMP biosynthetic process
A0016301molecular_functionkinase activity
A0019136molecular_functiondeoxynucleoside kinase activity
A0042803molecular_functionprotein homodimerization activity
A0043771molecular_functioncytidine kinase activity
A0106383biological_processdAMP salvage
A1901135biological_processcarbohydrate derivative metabolic process
A1901293biological_processnucleoside phosphate biosynthetic process
B0004136molecular_functiondeoxyadenosine kinase activity
B0004137molecular_functiondeoxycytidine kinase activity
B0004138molecular_functiondeoxyguanosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006139biological_processnucleobase-containing compound metabolic process
B0006220biological_processpyrimidine nucleotide metabolic process
B0008144molecular_functionobsolete drug binding
B0009224biological_processCMP biosynthetic process
B0016301molecular_functionkinase activity
B0019136molecular_functiondeoxynucleoside kinase activity
B0042803molecular_functionprotein homodimerization activity
B0043771molecular_functioncytidine kinase activity
B0106383biological_processdAMP salvage
B1901135biological_processcarbohydrate derivative metabolic process
B1901293biological_processnucleoside phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 1QC A 301
ChainResidue
AGLU53
ASER144
ATYR204
ALYS207
AVAL55
ALEU82
ATYR86
APRO89
AGLN97
AARG128
AASP133
APHE137

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE UDP A 302
ChainResidue
AALA31
AALA32
AGLY33
ALYS34
ASER35
ATHR36
AARG188
ALEU191
AARG192
AASP241
APHE242

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1QC B 301
ChainResidue
BGLU53
BLEU82
BTYR86
BPRO89
BPHE96
BGLN97
BARG128
BASP133
BPHE137
BPRO201
BTYR204

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE UDP B 302
ChainResidue
BASN29
BALA31
BALA32
BGLY33
BLYS34
BSER35
BTHR36
BARG188
BLEU191
BARG192
BASP241
BPHE242
BLYS243
BHOH439
BHOH448

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255
ChainResidueDetails
AGLU127
BGLU127

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING:
ChainResidueDetails
AGLY28
BGLY28
BGLU53
BTYR86
BGLN97
BARG128
BASP133
BARG188
BGLU197
BGLU240
AGLU53
ATYR86
AGLN97
AARG128
AASP133
AARG188
AGLU197
AGLU240

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000305|PubMed:20637175
ChainResidueDetails
ASER11
ASER15
BSER11
BSER15

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CK1 => ECO:0000305|PubMed:20637175
ChainResidueDetails
ATHR72
BTHR72

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20637175, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
AGLU74
BGLU74

227111

PDB entries from 2024-11-06

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