4KBN
human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine
Summary for 4KBN
Entry DOI | 10.2210/pdb4kbn/pdb |
Related | 4KAK 4KD7 4KEB 4KFJ |
Descriptor | Dihydrofolate reductase, 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ETHANOL, ... (9 entities in total) |
Functional Keywords | oxidoreductase, 5, 6, 7, 8-tetrahydrofolate, nadp+, hydride shift, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 45596.90 |
Authors | Lamb, K.M.,Anderson, A.C. (deposition date: 2013-04-23, release date: 2013-10-09, Last modification date: 2023-09-20) |
Primary citation | Lamb, K.M.,G-Dayanandan, N.,Wright, D.L.,Anderson, A.C. Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase. Biochemistry, 52:7318-7326, 2013 Cited by PubMed: 24053334DOI: 10.1021/bi400852h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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