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4KBN

human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine

Summary for 4KBN
Entry DOI10.2210/pdb4kbn/pdb
Related4KAK 4KD7 4KEB 4KFJ
DescriptorDihydrofolate reductase, 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ETHANOL, ... (9 entities in total)
Functional Keywordsoxidoreductase, 5, 6, 7, 8-tetrahydrofolate, nadp+, hydride shift, cytosol, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight45596.90
Authors
Lamb, K.M.,Anderson, A.C. (deposition date: 2013-04-23, release date: 2013-10-09, Last modification date: 2023-09-20)
Primary citationLamb, K.M.,G-Dayanandan, N.,Wright, D.L.,Anderson, A.C.
Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
Biochemistry, 52:7318-7326, 2013
Cited by
PubMed: 24053334
DOI: 10.1021/bi400852h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.84 Å)
Structure validation

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