4KBN
human dihydrofolate reductase complexed with NADPH and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 186 | 21349.5 | 2 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (human) | |
| 2 | C, O (A, B) | 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine | non-polymer | 330.4 | 2 | Chemie (25U) | |||
| 3 | D, P, Q (A, B) | ETHANOL | non-polymer | 46.1 | 3 | Chemie (EOH) | |||
| 4 | E, F, H, I, J... (A, B) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 5 | BA, G, K, M, S... (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 9 | Chemie (MG) | |||
| 6 | AA, L (B, A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 7 | N (B) | STRONTIUM ION | non-polymer | 87.6 | 1 | Chemie (SR) | |||
| 8 | X (B) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 9 | CA, DA (A, B) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42699.1 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2897.8 | |
| All* | Total formula weight | 45596.9 |
