4KAI
HCV NS5B GT1B N316 with GSK5852A
Summary for 4KAI
Entry DOI | 10.2210/pdb4kai/pdb |
Related | 4KB7 4KBI 4KE5 4KHM 4KHR |
Descriptor | HCV Polymerase, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid (3 entities in total) |
Functional Keywords | hcv polymerase, hcv ns5b, site iv inhibitor, boron, rna dependent rna polymerase, transferase-transferase inhibitor complex, replication-replication inhibitor complex, replication/replication inhibitor |
Biological source | Hepatitis C virus (HCV) |
Total number of polymer chains | 2 |
Total formula weight | 130862.93 |
Authors | Williams, S.P.,Kahler, K.M.,Shotwell, J.B. (deposition date: 2013-04-22, release date: 2013-05-08, Last modification date: 2024-03-13) |
Primary citation | Maynard, A.,Crosby, R.M.,Ellis, B.,Hamatake, R.,Hong, Z.,Johns, B.A.,Kahler, K.M.,Koble, C.,Leivers, A.,Leivers, M.R.,Mathis, A.,Peat, A.J.,Pouliot, J.J.,Roberts, C.D.,Samano, V.,Schmidt, R.M.,Smith, G.K.,Spaltenstein, A.,Stewart, E.L.,Thommes, P.,Turner, E.M.,Voitenleitner, C.,Walker, J.T.,Waitt, G.,Weatherhead, J.,Weaver, K.,Williams, S.,Wright, L.,Xiong, Z.Z.,Haigh, D.,Shotwell, J.B. Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57:1902-1913, 2014 Cited by PubMed: 23672667DOI: 10.1021/jm400317w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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