4KAI

HCV NS5B GT1B N316 with GSK5852A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	HCV Polymerase	polymer	577	64322.7	2	UniProt (P26663) Pfam (PF00998)	Hepatitis C virus (HCV)	RNA-directed RNA polymerase, NS5B, p68
2	C, D, E, F (A, B)	[4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid	non-polymer		554.4	4	Chemie (1PV)
3	G, H (A, B)	water	water		18.0	548	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: P26663)

PDB	External Database	Details
Met 0	-	initiating methionine
Gln 47	Leu 2466	engineered mutation
Tyr 101	Phe 2520	engineered mutation
Arg 114	Lys 2533	engineered mutation
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128645.4
Non-Polymers*	Number of molecules	4
	Total formula weight	2217.5
All*	Total formula weight	130862.9

*Water molecules are not included.