4KAI
HCV NS5B GT1B N316 with GSK5852A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | HCV Polymerase | polymer | 577 | 64322.7 | 2 | UniProt (P26663) Pfam (PF00998) In PDB | Hepatitis C virus (HCV) | RNA-directed RNA polymerase, NS5B, p68 |
2 | A, B | [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid | non-polymer | 554.4 | 4 | Chemie (1PV) | |||
3 | water | water | 18.0 | 548 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: P26663)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Gln 47 | Leu 2466 | engineered mutation |
Tyr 101 | Phe 2520 | engineered mutation |
Arg 114 | Lys 2533 | engineered mutation |
His 571 | - | expression tag |
His 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128645.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2217.5 | |
All* | Total formula weight | 130862.9 |