4K88
Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form)
Summary for 4K88
| Entry DOI | 10.2210/pdb4k88/pdb |
| Related | 4K86 4K87 |
| Descriptor | Proline--tRNA ligase, ZINC ION, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (4 entities in total) |
| Functional Keywords | class ii trna synthetase, ligase, zinc binding, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 61028.19 |
| Authors | Hwang, K.Y.,Son, J.H.,Lee, E.H. (deposition date: 2013-04-18, release date: 2013-10-09, Last modification date: 2024-03-20) |
| Primary citation | Son, J.,Lee, E.H.,Park, M.,Kim, J.H.,Kim, J.,Kim, S.,Jeon, Y.H.,Hwang, K.Y. Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69:2136-2145, 2013 Cited by PubMed: 24100331DOI: 10.1107/S0907444913020556 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.619 Å) |
Structure validation
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