4K88

Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proline--tRNA ligase	polymer	535	60548.1	1	UniProt (P07814) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) In PDB	Homo sapiens (human)	Prolyl-tRNA synthetase
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one	non-polymer		414.7	1	Chemie (HFG)
4		water	water		18.0	75	Chemie (HOH)

Sequence modifications

A: 0 - 512 (UniProt: P07814)

PDB	External Database	Details
Met -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Ser -12	-	expression tag
Ser -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60548.1
Non-Polymers*	Number of molecules	2
	Total formula weight	480.1
All*	Total formula weight	61028.2

*Water molecules are not included.