4K3J
Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta
Summary for 4K3J
Entry DOI | 10.2210/pdb4k3j/pdb |
Related | 1SHY |
Descriptor | Hepatocyte growth factor, Hepatocyte growth factor beta chain, Onartuzumab Fab heavy chain, ... (6 entities in total) |
Functional Keywords | antibody, glycosylation, transferase-immune system-growth factor complex, transferase/immune system/growth factor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 135381.99 |
Authors | Ma, X.,Starovasnik, M.A. (deposition date: 2013-04-10, release date: 2013-08-28, Last modification date: 2023-09-20) |
Primary citation | Merchant, M.,Ma, X.,Maun, H.R.,Zheng, Z.,Peng, J.,Romero, M.,Huang, A.,Yang, N.Y.,Nishimura, M.,Greve, J.,Santell, L.,Zhang, Y.W.,Su, Y.,Kaufman, D.W.,Billeci, K.L.,Mai, E.,Moffat, B.,Lim, A.,Duenas, E.T.,Phillips, H.S.,Xiang, H.,Young, J.C.,Vande Woude, G.F.,Dennis, M.S.,Reilly, D.E.,Schwall, R.H.,Starovasnik, M.A.,Lazarus, R.A.,Yansura, D.G. Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Proc.Natl.Acad.Sci.USA, 110:E2987-E2996, 2013 Cited by PubMed: 23882082DOI: 10.1073/pnas.1302725110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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