4K3J
Crystal structure of Onartuzumab Fab in complex with MET and HGF-beta
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor | polymer | 233 | 26038.1 | 1 | UniProt (P14210) Pfam (PF00089) In PDB | Homo sapiens (human) | Hepatopoietin-A, Scatter factor, SF, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain |
2 | B | Hepatocyte growth factor beta chain | polymer | 534 | 60758.9 | 1 | UniProt (P08581) Pfam (PF01403) Pfam (PF01437) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
3 | H | Onartuzumab Fab heavy chain | polymer | 224 | 24000.8 | 1 | Mus musculus Homo sapiens | ||
4 | L | Onartuzumab Fab light chain | polymer | 220 | 24363.0 | 1 | Mus musculus Homo sapiens | ||
5 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
6 | water | water | 18.0 | 183 | Chemie (HOH) |
Sequence modifications
A: 495 - 721 (UniProt: P14210)
B: 39 - 564 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Ser 604 | Cys 604 | engineered mutation |
His 722 | - | expression tag |
His 723 | - | expression tag |
His 724 | - | expression tag |
His 725 | - | expression tag |
His 726 | - | expression tag |
His 727 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 565 | - | expression tag |
His 566 | - | expression tag |
His 567 | - | expression tag |
His 568 | - | expression tag |
His 569 | - | expression tag |
His 570 | - | expression tag |
His 571 | - | expression tag |
His 572 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 135160.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 135382.0 |