4JY4
Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody
Summary for 4JY4
Entry DOI | 10.2210/pdb4jy4/pdb |
Related | 4JY5 4JY6 |
Descriptor | PGT121 heavy chain, PGT121 light chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | broadly neutralizing antibody against hiv-1, hiv-1 env gp120 subunit, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 49734.01 |
Authors | Julien, J.-P.,Diwanji, D.C.,Burton, D.R.,Wilson, I.A. (deposition date: 2013-03-29, release date: 2013-05-15, Last modification date: 2023-09-20) |
Primary citation | Julien, J.P.,Sok, D.,Khayat, R.,Lee, J.H.,Doores, K.J.,Walker, L.M.,Ramos, A.,Diwanji, D.C.,Pejchal, R.,Cupo, A.,Katpally, U.,Depetris, R.S.,Stanfield, R.L.,McBride, R.,Marozsan, A.J.,Paulson, J.C.,Sanders, R.W.,Moore, J.P.,Burton, D.R.,Poignard, P.,Ward, A.B.,Wilson, I.A. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathog., 9:e1003342-e1003342, 2013 Cited by PubMed: 23658524DOI: 10.1371/journal.ppat.1003342 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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