4JT5
mTORdeltaN-mLST8-pp242 complex
Summary for 4JT5
Entry DOI | 10.2210/pdb4jt5/pdb |
Descriptor | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 Cytoplasm (By similarity): Q9BVC4 |
Total number of polymer chains | 4 |
Total formula weight | 341737.36 |
Authors | Pavletich, N.P.,Yang, H. (deposition date: 2013-03-22, release date: 2013-05-08, Last modification date: 2024-02-28) |
Primary citation | Yang, H.,Rudge, D.G.,Koos, J.D.,Vaidialingam, B.,Yang, H.J.,Pavletich, N.P. mTOR kinase structure, mechanism and regulation. Nature, 497:217-223, 2013 Cited by PubMed: 23636326DOI: 10.1038/nature12122 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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