4JQL
Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
Summary for 4JQL
Entry DOI | 10.2210/pdb4jql/pdb |
Descriptor | Heat shock protein HSP 90-alpha, valerjesomycin, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | inhibitor design, hsp90, nucleotide binding domain, chaperone, geldanamycin, cytosole, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 28547.28 |
Authors | Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C. (deposition date: 2013-03-20, release date: 2013-04-10, Last modification date: 2024-02-28) |
Primary citation | Jeso, V.,Iqbal, S.,Hernandez, P.,Cameron, M.D.,Park, H.,Lograsso, P.V.,Micalizio, G.C. Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic Acid. Angew.Chem.Int.Ed.Engl., 52:4800-4804, 2013 Cited by PubMed: 23554224DOI: 10.1002/anie.201301323 PDB entries with the same primary citation |
Experimental method |
Structure validation
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