4JMU

Crystal structure of HIV matrix residues 1-111 in complex with inhibitor

Summary for 4JMU

Entry DOI	10.2210/pdb4jmu/pdb
Descriptor	Gag-Pol polyprotein, SULFATE ION, 5-{4-[(4-methoxybenzoyl)amino]phenoxy}-2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}benzoic acid, ... (4 entities in total)
Functional Keywords	structural protein matrix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) (HIV-1)
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
Total number of polymer chains	1
Total formula weight	13408.28
Authors	Lemke, C.T. (deposition date: 2013-03-14, release date: 2013-10-30, Last modification date: 2024-02-28)
Primary citation	Laplante, S.R.,Forgione, P.,Boucher, C.,Coulombe, R.,Gillard, J.,Hucke, O.,Jakalian, A.,Joly, M.A.,Kukolj, G.,Lemke, C.,McCollum, R.,Titolo, S.,Beaulieu, P.L.,Stammers, T. Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity. J.Med.Chem., 57:1944-1951, 2014 Cited by PubMed: 24024973 DOI: 10.1021/jm401202a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation