4JMU

Crystal structure of HIV matrix residues 1-111 in complex with inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005198	molecular_function	structural molecule activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	ARG22
A	LYS26
A	LYS27
A	HOH302

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1ML A 202

Chain	Residue
A	HIS33
A	TRP36
A	GLU73
A	GLU74
A	SER77
A	ASN80
A	THR81
A	THR97
A	LYS110
A	HOH334
A	HOH377
A	LEU21
A	ARG22
A	PRO23
A	TYR29
A	LYS32

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Interaction with Gp41","evidences":[{"source":"PubMed","id":"8918455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Region: {"description":"Interaction with host CALM1","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Region: {"description":"Interaction with host AP3D1","evidences":[{"source":"PubMed","id":"15766529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	Region: {"description":"Interaction with membrane phosphatidylinositol 4,5-bisphosphate and RNA","evidences":[{"source":"PubMed","id":"16840558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Region: {"description":"Interaction with membrane phosphatidylinositol 4,5-bisphosphate","evidences":[{"source":"PubMed","id":"16840558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---