4JLJ
Human dCK C4S-S74E mutant in complex with UDP and the F2.1.1 inhibitor (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)
Summary for 4JLJ
Entry DOI | 10.2210/pdb4jlj/pdb |
Related | 4JLK 4JLM |
Descriptor | Deoxycytidine kinase, 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | phosphoryl transfer, phosphorylation, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 2 |
Total formula weight | 67841.52 |
Authors | |
Primary citation | Nomme, J.,Murphy, J.M.,Su, Y.,Sansone, N.D.,Armijo, A.L.,Olson, S.T.,Radu, C.,Lavie, A. Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules. Acta Crystallogr.,Sect.D, 70:68-78, 2014 Cited by PubMed: 24419380DOI: 10.1107/S1399004713025030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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