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4JL4

Crystal structure of the complex between PPARgamma LBD and the ligand LJ570 [(2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid]

Summary for 4JL4
Entry DOI10.2210/pdb4jl4/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-3-(biphenyl-4-yl)-2-(biphenyl-4-yloxy)propanoic acid (3 entities in total)
Functional Keywordsbundle of alpha-helices, small four-strnded beta-sheet, transcription factor, rxr, transcription-agonist complex, transcription/agonist
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight65782.11
Authors
Pochetti, G.,Montanari, R.,Capelli, D. (deposition date: 2013-03-12, release date: 2014-03-12, Last modification date: 2023-08-02)
Primary citationLaghezza, A.,Piemontese, L.,Cerchia, C.,Montanari, R.,Capelli, D.,Giudici, M.,Crestani, M.,Tortorella, P.,Peiretti, F.,Pochetti, G.,Lavecchia, A.,Loiodice, F.
Identification of the First PPAR alpha / gamma Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR gamma and To Inhibit Its Cdk5-Mediated Phosphorylation.
J.Med.Chem., 61:8282-8298, 2018
Cited by
PubMed: 30199253
DOI: 10.1021/acs.jmedchem.8b00835
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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