Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4JIT

Crystal Structure of E. coli XGPRT in complex with (S)-3-(Guanin-9-yl)pyrrolidin-N-ylacetylphosphonic acid

Summary for 4JIT
Entry DOI10.2210/pdb4jit/pdb
Related4JLS
DescriptorXanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid (3 entities in total)
Functional Keywordsxanthine-guanine phosphoribosyltransferase, purine salvage, nucleoside phosphonate, antibacterial, transferase
Biological sourceEscherichia coli
Cellular locationCell membrane ; Peripheral membrane protein : H0Q6L9
Total number of polymer chains4
Total formula weight68650.77
Authors
Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.J.,de Jersey, J.,Guddat, L.W. (deposition date: 2013-03-07, release date: 2014-12-24, Last modification date: 2024-02-28)
Primary citationKeough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.,de Jersey, J.,Guddat, L.W.
Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56:6967-6984, 2013
Cited by
PubMed: 23927482
DOI: 10.1021/jm400779n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon