4JLS

Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid

Summary for 4JLS

• Entry DOI: 10.2210/pdb4jls/pdb
• Related: 4JIT
• Descriptor: Xanthine phosphoribosyltransferase, {2-[(3S,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxypyrrolidin-1-yl]-2-oxoethyl}phosphonic acid (3 entities in total)
• Functional Keywords: xanthine-guanine phosphoribosyltransferase, purine salvage, nucleoside phosphonate, antibacterial, transferase
• Biological source: Escherichia coli
• Cellular location: Cell membrane ; Peripheral membrane protein : H0Q6L9
• Total number of polymer chains: 8
• Total formula weight: 138798.52

Authors

Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.J.,de Jersey, J.,Guddat, L.W. (deposition date: 2013-03-12, release date: 2014-12-24, Last modification date: 2024-02-28)

• Primary citation: Keough, D.T.,Hockova, D.,Rejman, D.,Spacek, P.,Vrbkova, S.,Krecmerova, M.,Eng, W.S.,Jans, H.,West, N.P.,Naesens, L.M.,de Jersey, J.,Guddat, L.W.; Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.; J.Med.Chem., 56:6967-6984, 2013; PubMed: 23927482; DOI: 10.1021/jm400779n

Experimental method

X-RAY DIFFRACTION (2.2 Å)