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4JGF

Crystal Structure of the Cataract-Causing P23T gamma D-Crystallin Mutant

Summary for 4JGF
Entry DOI10.2210/pdb4jgf/pdb
DescriptorGamma-crystallin D (2 entities in total)
Functional Keywordsstructural protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight40809.41
Authors
Ji, F.L.,Koharudin, L.M.,Jung, J.W.,Gronenborn, A.M. (deposition date: 2013-03-01, release date: 2013-05-22, Last modification date: 2024-02-28)
Primary citationJi, F.,Koharudin, L.M.,Jung, J.,Gronenborn, A.M.
Crystal structure of the cataract-causing P23T gamma D-crystallin mutant.
Proteins, 81:1493-1498, 2013
Cited by
PubMed Abstract: Up to now, efforts to crystallize the cataract-associated P23T mutant of human γD-crystallin have not been successful. Therefore, insights into the light scattering mechanism of this mutant have been exclusively obtained from solution work. Here we present the first crystal structure of the P23T mutant at 2.5 Å resolution. The protein exhibits essentially the same overall structure as seen for the wild-type protein. Based on our structural data, we confirm that no major conformational changes are caused by the mutation, and that solution phase properties of the mutant appear exclusively associated with cataract formation.
PubMed: 23670788
DOI: 10.1002/prot.24321
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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