4J99

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.

Summary for 4J99

Entry DOI	10.2210/pdb4j99/pdb
Related	2PSQ 2PVF 4J95 4J96 4J97 4J98
Descriptor	Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	bilobate protein kinase fold, receptor tyrosine kinase, atp binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	4
Total formula weight	151096.22
Authors	Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2023-09-20)
Primary citation	Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M. Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4:376-384, 2013 Cited by PubMed: 23871672 DOI: 10.1016/j.celrep.2013.06.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8474 Å)

Structure validation