4IWZ
structure of hCAII in complex with an acetazolamide derivative
Summary for 4IWZ
Entry DOI | 10.2210/pdb4iwz/pdb |
Descriptor | Carbonic anhydrase 2, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-2-(thiophen-2-yl)acetamide, ZINC ION, ... (6 entities in total) |
Functional Keywords | alpha beta fold, reversible hydration of carbon di oxide to bicarbonate and proton, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29656.83 |
Authors | Biswas, S.,McKenna, R. (deposition date: 2013-01-24, release date: 2013-12-11, Last modification date: 2024-02-28) |
Primary citation | Biswas, S.,McKenna, R.,Supuran, C.T. Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII. Bioorg.Med.Chem.Lett., 23:5646-5649, 2013 Cited by PubMed: 23993330DOI: 10.1016/j.bmcl.2013.08.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.598 Å) |
Structure validation
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