4ISF
Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide
Summary for 4ISF
Entry DOI | 10.2210/pdb4isf/pdb |
Related | 4ISE 4ISG |
Descriptor | Glucokinase, alpha-D-glucopyranose, (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total) |
Functional Keywords | transferase/activator activity, glucose conversion to g6p, phosphorylation, transferase-transferase activator complex, transferase/transferase activator |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 52116.06 |
Authors | Hosfield, D.,Skene, R.J. (deposition date: 2013-01-16, release date: 2013-03-20, Last modification date: 2024-02-28) |
Primary citation | Cheruvallath, Z.S.,Gwaltney, S.L.,Sabat, M.,Tang, M.,Feng, J.,Wang, H.,Miura, J.,Guntupalli, P.,Jennings, A.,Hosfield, D.,Lee, B.,Wu, Y. Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23:2166-2171, 2013 Cited by PubMed: 23434031DOI: 10.1016/j.bmcl.2013.01.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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