4ISF
Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucokinase | polymer | 458 | 51392.5 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB | Homo sapiens (human) | Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
2 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
3 | A | (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide | non-polymer | 416.5 | 1 | Chemie (1FX) | |||
4 | A | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
5 | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
A: 16 - 465 (UniProt: P35557)
PDB | External Database | Details |
---|---|---|
Met 8 | - | expression tag |
Lys 9 | - | expression tag |
Pro 10 | - | expression tag |
Met 11 | - | expression tag |
Pro 12 | - | expression tag |
Leu 13 | - | expression tag |
Thr 14 | - | expression tag |
Leu 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51392.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 723.5 | |
All* | Total formula weight | 52116.1 |