4I7F
HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine
Summary for 4I7F
Entry DOI | 10.2210/pdb4i7f/pdb |
Descriptor | Reverse transcriptase, diethyl ({4-[2-(11-ethyl-5-methyl-6-oxo-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-8-yl)ethyl]phenoxy}methyl)phosphonate, SULFATE ION, ... (7 entities in total) |
Functional Keywords | nnrti, hiv, reverse transcriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116966.01 |
Authors | Lansdon, E.B.,Parrish, J. (deposition date: 2012-11-30, release date: 2013-02-20, Last modification date: 2023-09-20) |
Primary citation | Parrish, J.,Tong, L.,Wang, M.,Chen, X.,Lansdon, E.B.,Cannizzaro, C.,Zheng, X.,Desai, M.C.,Xu, L. Synthesis and biological evaluation of phosphonate analogues of nevirapine. Bioorg.Med.Chem.Lett., 23:1493-1497, 2013 Cited by PubMed: 23375792DOI: 10.1016/j.bmcl.2012.12.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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