4I0J

SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors

Summary for 4I0J

• Entry DOI: 10.2210/pdb4i0j/pdb
• Related: 4I0H 4I0I
• Descriptor: Beta-secretase 1, ZINC ION, N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(1H-pyrazol-1-yl)phenyl]cyclohexyl}amino)propyl]acetamide, ... (4 entities in total)
• Functional Keywords: bace asp protease, hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 1
• Total formula weight: 46189.32

Authors

Yao, N.,Brecht, E. (deposition date: 2012-11-16, release date: 2013-03-06)

• Primary citation: Mondal, K.,Regnstrom, K.,Morishige, W.,Barbour, R.,Beroza, P.,Yao, N.,Bova, M.P.; SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.99 Å)