4I0H
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.
Summary for 4I0H
Entry DOI | 10.2210/pdb4i0h/pdb |
Related | 4I0I 4I0J |
Descriptor | Beta-secretase 1, (2R)-5-{[(2S,3R)-4-{[1-(3-tert-butylphenyl)cyclohexyl]amino}-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]amino}-2-hydroxy-5-oxopentanoic acid (3 entities in total) |
Functional Keywords | bace, asp protease, hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 138017.38 |
Authors | |
Primary citation | Mondal, K.,Regnstrom, K.,Morishige, W.,Barbour, R.,Beroza, P.,Yao, N.,Bova, M.P. SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report