4HBU
Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)
Summary for 4HBU
Entry DOI | 10.2210/pdb4hbu/pdb |
Related | 4GZB 4HBT 4HEF |
Descriptor | Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | hydrolysis of beta-lactams, antibiotic resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 29446.47 |
Authors | Docquier, J.D.,Benvenuti, M.,Bruneau, J.M.,Rossolini, G.M.,Miossec, C.,Black, M.T.,Mangani, S. (deposition date: 2012-09-28, release date: 2013-04-10, Last modification date: 2023-11-08) |
Primary citation | Lahiri, S.D.,Mangani, S.,Durand-Reville, T.,Benvenuti, M.,De Luca, F.,Sanyal, G.,Docquier, J.D. Structural insight into potent broad-spectrum inhibition with reversible recyclization mechanism: avibactam in complex with CTX-M-15 and Pseudomonas aeruginosa AmpC beta-lactamases Antimicrob.Agents Chemother., 57:2496-2505, 2013 Cited by PubMed: 23439634DOI: 10.1128/AAC.02247-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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