4H1L

TCR interaction with peptide mimics of nickel offers structural insights in nickel contact allergy

Summary for 4H1L

• Entry DOI: 10.2210/pdb4h1l/pdb
• Related: 4H25 4H26
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen, mimotope peptide, ... (5 entities in total)
• Functional Keywords: protein-protein complex, immunoglobin fold, tcr recogniton of mhc, mhc ii, glycosidation, membrane, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903
• Total number of polymer chains: 10
• Total formula weight: 138353.32

Authors

Kappler, J.W.,Yin, L.,Dai, S.,Marrack, P. (deposition date: 2012-09-10, release date: 2012-11-14, Last modification date: 2013-09-04)

• Primary citation: Yin, L.,Crawford, F.,Marrack, P.,Kappler, J.W.,Dai, S.; T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.; Proc.Natl.Acad.Sci.USA, 109:18517-18522, 2012; PubMed: 23091041; DOI: 10.1073/pnas.1215928109

Experimental method

X-RAY DIFFRACTION (3.3 Å)