4GW4
Crystal structure of 3BNC60 Fab with P61A mutation
Summary for 4GW4
Entry DOI | 10.2210/pdb4gw4/pdb |
Descriptor | 3BNC60 Fab Light-chain, 3BNC60 Fab Heavy-chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | fwr, igg, anti hiv, gp120, hiv, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 96325.27 |
Authors | Diskin, R.,Fu, B.Z.,Bjorkman, P.J. (deposition date: 2012-08-31, release date: 2013-04-17, Last modification date: 2020-07-29) |
Primary citation | Klein, F.,Diskin, R.,Scheid, J.F.,Gaebler, C.,Mouquet, H.,Georgiev, I.S.,Pancera, M.,Zhou, T.,Incesu, R.B.,Fu, B.Z.,Gnanapragasam, P.N.,Oliveira, T.Y.,Seaman, M.S.,Kwong, P.D.,Bjorkman, P.J.,Nussenzweig, M.C. Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell(Cambridge,Mass.), 153:126-138, 2013 Cited by PubMed: 23540694DOI: 10.1016/j.cell.2013.03.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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