4GRB
Casein kinase 2 (CK2) bound to inhibitor
Summary for 4GRB
Entry DOI | 10.2210/pdb4grb/pdb |
Related | 3U4U |
Descriptor | Casein kinase II subunit alpha, CHLORIDE ION, 5-(2-{[4-(dimethylcarbamoyl)phenyl]amino}-4-methoxypyrimidin-5-yl)thiophene-3-carboxylic acid, ... (4 entities in total) |
Functional Keywords | kinase, protein kinase, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40312.39 |
Authors | Larsen, N.A.,Dowling, J.E.,Ferguson, A.D. (deposition date: 2012-08-24, release date: 2013-08-28, Last modification date: 2024-02-28) |
Primary citation | Dowling, J.E.,Alimzhanov, M.,Bao, L.,Block, M.H.,Chuaqui, C.,Cooke, E.L.,Denz, C.R.,Hird, A.,Huang, S.,Larsen, N.A.,Peng, B.,Pontz, T.W.,Rivard-Costa, C.,Saeh, J.C.,Thakur, K.,Ye, Q.,Zhang, T.,Lyne, P.D. Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett, 4:800-805, 2013 Cited by PubMed: 24900749DOI: 10.1021/ml400197u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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