4GD4

Crystal Structure of JMJD2A Complexed with Inhibitor

Summary for 4GD4

• Entry DOI: 10.2210/pdb4gd4/pdb
• Descriptor: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, oxidoreductase, jmjc domain, chromatin regulator, dioxygenase, transcription, demethylation, iron, 2-oxoglutarate, alpha-ketoglutarate, nucleus, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : O75164
• Total number of polymer chains: 2
• Total formula weight: 89420.90

Authors

King, O.N.F.,Krojer, T.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,McDonough, M.A.,Schofield, C.J.,Structural Genomics Consortium (SGC) (deposition date: 2012-07-31, release date: 2012-08-15, Last modification date: 2024-02-28)

• Primary citation: King, O.N.F.,Krojer, T.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,McDonough, M.A.,Schofield, C.J.,Structural Genomics Consortium (SGC); Crystal Structure of JMJD2A Complexed with Inhibitor; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.33 Å)