4G3X
Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase
Summary for 4G3X
Entry DOI | 10.2210/pdb4g3x/pdb |
Related | 4G0N |
Descriptor | GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | h-ras, ras, raf kinase, raf, gtpase, allosteric regulation, intrinsic hydrolysis, protein-protein interaction, kinase, gtp binding, hydrolase-transferase complex, hydrolase/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 Cytoplasm: P04049 |
Total number of polymer chains | 2 |
Total formula weight | 28196.01 |
Authors | Fetics, S.K.,Kearney, B.M.,Buhrman, G.,Mattos, C. (deposition date: 2012-07-15, release date: 2013-07-17, Last modification date: 2023-09-13) |
Primary citation | Fetics, S.K.,Guterres, H.,Kearney, B.M.,Buhrman, G.,Ma, B.,Nussinov, R.,Mattos, C. Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD. Structure, 23:505-516, 2015 Cited by PubMed: 25684575DOI: 10.1016/j.str.2014.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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