4G3E
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)
Summary for 4G3E
Entry DOI | 10.2210/pdb4g3e/pdb |
Related | 4G3C 4G3D 4G3F 4G3G |
Descriptor | NF-kappa-beta-inducing kinase, SULFATE ION, (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, ... (4 entities in total) |
Functional Keywords | non-rd kinase, protein serine/threonine kinase, nf-kappab, structure-based drug design, map3k14, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm: Q9WUL6 |
Total number of polymer chains | 2 |
Total formula weight | 78687.31 |
Authors | Hymowitz, S.G.,de Leon-Boenig, G. (deposition date: 2012-07-13, release date: 2012-08-15, Last modification date: 2024-04-03) |
Primary citation | de Leon-Boenig, G.,Bowman, K.K.,Feng, J.A.,Crawford, T.,Everett, C.,Franke, Y.,Oh, A.,Stanley, M.,Staben, S.T.,Starovasnik, M.A.,Wallweber, H.J.,Wu, J.,Wu, L.C.,Johnson, A.R.,Hymowitz, S.G. The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20:1704-1714, 2012 Cited by PubMed: 22921830DOI: 10.1016/j.str.2012.07.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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