4G3E
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NF-kappa-beta-inducing kinase | polymer | 352 | 38801.7 | 2 | UniProt (Q9WUL6) Pfam (PF00069) | Mus musculus (mouse) | Serine/threonine-protein kinase NIK |
| 2 | C, D, F (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E, G (A, B) | (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol | non-polymer | 397.9 | 2 | Chemie (0WC) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
A, B: 329 - 675 (UniProt: Q9WUL6)
| PDB | External Database | Details |
|---|---|---|
| Gly 327 | - | expression tag |
| Ser 328 | - | expression tag |
| Gly 676 | - | expression tag |
| Asn 677 | - | expression tag |
| Ser 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77603.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1084.0 | |
| All* | Total formula weight | 78687.3 |
