4G1F

Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue

Summary for 4G1F

Entry DOI	10.2210/pdb4g1f/pdb
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ... (5 entities in total)
Functional Keywords	protease, 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	349441.22
Authors	Skene, R.J.,Gwaltney, S.L. (deposition date: 2012-07-10, release date: 2013-02-27, Last modification date: 2024-11-06)
Primary citation	Lam, B.,Zhang, Z.,Stafford, J.A.,Skene, R.J.,Shi, L.,Gwaltney, S.L. Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 22:6628-6631, 2012 Cited by PubMed Abstract: Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors. PubMed: 23025999 DOI: 10.1016/j.bmcl.2012.08.110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation