4FZB
Structure of thymidylate synthase ThyX complexed to a new inhibitor
Summary for 4FZB
Entry DOI | 10.2210/pdb4fzb/pdb |
Descriptor | Probable thymidylate synthase, FLAVIN-ADENINE DINUCLEOTIDE, 2-hydroxy-3-(4-methoxybenzyl)naphthalene-1,4-dione, ... (5 entities in total) |
Functional Keywords | homotetramer, fad-dependent thymidylate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Paramecium bursaria Chlorella virus 1 (PBCV-1) |
Total number of polymer chains | 16 |
Total formula weight | 437697.38 |
Authors | Basta, T.,Boum, Y.,Briffotaux, J.,Becker, H.F.,Lamarre-Jouenne, I.,Lambry, J.C.,Skouloubris, S.,Liebl, U.,van Tilbeurgh, H.,Graille, M.,Myllylkallio, H. (deposition date: 2012-07-06, release date: 2013-05-22, Last modification date: 2023-09-13) |
Primary citation | Basta, T.,Boum, Y.,Briffotaux, J.,Becker, H.F.,Lamarre-Jouenne, I.,Lambry, J.C.,Skouloubris, S.,Liebl, U.,Graille, M.,van Tilbeurgh, H.,Myllykallio, H. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biology, 2:120120-120120, 2012 Cited by PubMed: 23155486DOI: 10.1098/rsob.120120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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