4FNY
Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor
Summary for 4FNY
Entry DOI | 10.2210/pdb4fny/pdb |
Related | 4FNW 4FNX 4FNZ 4FOB 4FOC 4FOD |
Descriptor | ALK tyrosine kinase receptor, N-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, cd246, phosphotransferase, npm-alk, eml4-alk, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 37252.01 |
Authors | Whittington, D.A.,Epstein, L.F.,Chen, H. (deposition date: 2012-06-20, release date: 2012-08-29, Last modification date: 2024-02-28) |
Primary citation | Epstein, L.F.,Chen, H.,Emkey, R.,Whittington, D.A. The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. J.Biol.Chem., 287:37447-37457, 2012 Cited by PubMed: 22932897DOI: 10.1074/jbc.M112.391425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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