4FM5

X-ray structure of des-methylflurbiprofen bound to murine COX-2

Summary for 4FM5

Entry DOI	10.2210/pdb4fm5/pdb
Related	3NT1 3RR3
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (6 entities in total)
Functional Keywords	membrane protein, cyclooxygenase, heme binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	283210.36
Authors	Xu, S.,Banerjee, S.,Windsor, M.A.,Marnett, L.J. (deposition date: 2012-06-15, release date: 2012-08-29, Last modification date: 2023-09-13)
Primary citation	Windsor, M.A.,Hermanson, D.J.,Kingsley, P.J.,Xu, S.,Crews, B.C.,Ho, W.,Keenan, C.M.,Banerjee, S.,Sharkey, K.A.,Marnett, L.J. Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes. ACS Med Chem Lett, 3:759-763, 2012 Cited by PubMed: 22984634 DOI: 10.1021/ml3001616 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.81 Å)

Structure validation