4FM5
X-ray structure of des-methylflurbiprofen bound to murine COX-2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004601 | molecular_function | peroxidase activity |
A | 0006979 | biological_process | response to oxidative stress |
A | 0020037 | molecular_function | heme binding |
B | 0004601 | molecular_function | peroxidase activity |
B | 0006979 | biological_process | response to oxidative stress |
B | 0020037 | molecular_function | heme binding |
C | 0004601 | molecular_function | peroxidase activity |
C | 0006979 | biological_process | response to oxidative stress |
C | 0020037 | molecular_function | heme binding |
D | 0004601 | molecular_function | peroxidase activity |
D | 0006979 | biological_process | response to oxidative stress |
D | 0020037 | molecular_function | heme binding |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00298, ECO:0000269|PubMed:20463020 |
Chain | Residue | Details |
A | HIS207 | |
B | HIS207 | |
C | HIS207 | |
D | HIS207 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: For cyclooxygenase activity => ECO:0000269|PubMed:20463020 |
Chain | Residue | Details |
A | TYR385 | |
B | TYR385 | |
C | TYR385 | |
D | TYR385 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20463020, ECO:0007744|PDB:3KRK |
Chain | Residue | Details |
A | ARG120 | |
A | TYR355 | |
B | ARG120 | |
B | TYR355 | |
C | ARG120 | |
C | TYR355 | |
D | ARG120 | |
D | TYR355 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:12925531, ECO:0000269|PubMed:20463020, ECO:0000269|PubMed:20810665, ECO:0000269|PubMed:21489986, ECO:0000269|PubMed:8967954, ECO:0007744|PDB:1CX2, ECO:0007744|PDB:1PXX, ECO:0007744|PDB:3LN0, ECO:0007744|PDB:3LN1, ECO:0007744|PDB:3MQE, ECO:0007744|PDB:3NTB, ECO:0007744|PDB:3NTG, ECO:0007744|PDB:3PGH, ECO:0007744|PDB:4COX, ECO:0007744|PDB:4FM5, ECO:0007744|PDB:4M10, ECO:0007744|PDB:4M11, ECO:0007744|PDB:4PH9, ECO:0007744|PDB:5COX, ECO:0007744|PDB:6COX |
Chain | Residue | Details |
A | HIS388 | |
B | HIS388 | |
C | HIS388 | |
D | HIS388 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Aspirin-acetylated serine |
Chain | Residue | Details |
A | SER530 | |
B | SER530 | |
C | SER530 | |
D | SER530 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Not glycosylated => ECO:0000269|PubMed:8349699 |
Chain | Residue | Details |
A | ASN606 | |
B | ASN606 | |
C | ASN606 | |
D | ASN606 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P35354 |
Chain | Residue | Details |
A | CYS540 | |
B | CYS540 | |
C | CYS540 | |
D | CYS540 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: O-acetylserine; by SPHK1 => ECO:0000269|PubMed:29662056 |
Chain | Residue | Details |
A | SER579 | |
B | SER579 | |
C | SER579 | |
D | SER579 |
Chain | Residue | Details |
A | ASN67 | |
B | ASN67 | |
C | ASN67 | |
D | ASN67 |
Chain | Residue | Details |
A | ASN144 | |
B | ASN144 | |
C | ASN144 | |
D | ASN144 |
Chain | Residue | Details |
A | ASN410 | |
B | ASN410 | |
C | ASN410 | |
D | ASN410 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20463020, ECO:0000269|PubMed:8349699 |
Chain | Residue | Details |
A | ASN594 | |
B | ASN594 | |
C | ASN594 | |
D | ASN594 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 37 |
Chain | Residue | Details |
A | GLN203 | electrostatic stabiliser, hydrogen bond donor |
A | HIS207 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | LEU384 | steric role |
A | TYR385 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser |
A | HIS388 | metal ligand |
A | GLY526 | steric role |
A | SER530 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 37 |
Chain | Residue | Details |
B | GLN203 | electrostatic stabiliser, hydrogen bond donor |
B | HIS207 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | LEU384 | steric role |
B | TYR385 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser |
B | HIS388 | metal ligand |
B | GLY526 | steric role |
B | SER530 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 7 |
Details | M-CSA 37 |
Chain | Residue | Details |
C | GLN203 | electrostatic stabiliser, hydrogen bond donor |
C | HIS207 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
C | LEU384 | steric role |
C | TYR385 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser |
C | HIS388 | metal ligand |
C | GLY526 | steric role |
C | SER530 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 7 |
Details | M-CSA 37 |
Chain | Residue | Details |
D | GLN203 | electrostatic stabiliser, hydrogen bond donor |
D | HIS207 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
D | LEU384 | steric role |
D | TYR385 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, radical stabiliser |
D | HIS388 | metal ligand |
D | GLY526 | steric role |
D | SER530 | electrostatic stabiliser |