4FGG
S. aureus dihydrofolate reductase co-crystallized with propyl-DAP isobutenyl-dihydrophthalazine inhibitor
Summary for 4FGG
Entry DOI | 10.2210/pdb4fgg/pdb |
Related | 3M08 4FGH |
Descriptor | Dihydrofolate reductase, (2E)-3-{5-[(2,4-diamino-6-propylpyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-yl]prop-2-en-1-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | dihydrofolate reductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 20118.69 |
Authors | Bourne, C.R.,Barrow, W.W. (deposition date: 2012-06-04, release date: 2013-01-09, Last modification date: 2024-02-28) |
Primary citation | Nammalwar, B.,Bourne, C.R.,Bunce, R.A.,Wakeham, N.,Bourne, P.C.,Ramnarayan, K.,Mylvaganam, S.,Berlin, K.D.,Barrow, E.W.,Barrow, W.W. Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines. Chemmedchem, 7:1974-1982, 2012 Cited by PubMed: 22930550DOI: 10.1002/cmdc.201200291 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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