4FFY

Crystal structure of DENV1-E111 single chain variable fragment bound to DENV-1 DIII, strain 16007.

Summary for 4FFY

• Entry DOI: 10.2210/pdb4ffy/pdb
• Related: 3IRC 4FFZ
• Descriptor: DENV1-E111 single chain variable fragment (light chain), DENV1-E111 single chain variable fragment (heavy chain), envelope glycoprotein, ... (7 entities in total)
• Functional Keywords: viral envelope proteins, structural genomics, antibody epitopes, flavivirus, dengue virus, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Mus musculus; More
• Cellular location: Envelope protein E: Virion membrane; Multi- pass membrane protein: Q9J7C6
• Total number of polymer chains: 3
• Total formula weight: 40230.40

Authors

Austin, S.K.,Nelson, C.A.,Fremont, D.H.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-06-01, release date: 2012-06-20, Last modification date: 2012-10-31)

• Primary citation: Austin, S.K.,Dowd, K.A.,Shrestha, B.,Nelson, C.A.,Edeling, M.A.,Johnson, S.,Pierson, T.C.,Diamond, M.S.,Fremont, D.H.; Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope.; Plos Pathog., 8:e1002930-e1002930, 2012; PubMed: 23055922; DOI: 10.1371/journal.ppat.1002930

Experimental method

X-RAY DIFFRACTION (2.5 Å)