4F3K
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A
Summary for 4F3K
Entry DOI | 10.2210/pdb4f3k/pdb |
Related | 4F1W 4F2P 4F2W 4F3C |
Descriptor | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, {(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl}-L-methionine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | l-methionine biosynthetic process from s-adenosylmethionine, l-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, hydrolase activity, acting on glycosyl bonds, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Choleraesuis |
Total number of polymer chains | 2 |
Total formula weight | 53533.21 |
Authors | Haapalainen, A.M.,Thomas, K.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2012-05-09, release date: 2013-05-01, Last modification date: 2024-02-28) |
Primary citation | Haapalainen, A.M.,Thomas, K.,Tyler, P.C.,Evans, G.B.,Almo, S.C.,Schramm, V.L. Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A Structure, 21:963-974, 2013 Cited by PubMed: 23685211DOI: 10.1016/j.str.2013.04.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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