4ENH

Crystal Structure of Human Cytochrome P450 CYP46A1 with Fluvoxamine Bound

Summary for 4ENH

Entry DOI	10.2210/pdb4enh/pdb
Related	2Q9F 2Q9G 3MDM 3MDR 3MDT 3MDV
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, Fluvoxamine, ... (4 entities in total)
Functional Keywords	enzyme, p450, fluvoxamine, oxidoreductase, endoplasmic reticulum
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains	1
Total formula weight	53059.91
Authors	Stout, C.D.,Mast, N.,Pikuleva, I.A. (deposition date: 2012-04-13, release date: 2012-08-22, Last modification date: 2023-09-13)
Primary citation	Mast, N.,Linger, M.,Clark, M.,Wiseman, J.,Stout, C.D.,Pikuleva, I.A. In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine. Mol.Pharmacol., 82:824-834, 2012 Cited by PubMed: 22859721 DOI: 10.1124/mol.112.080424 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation