4EHG
B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor
Summary for 4EHG
Entry DOI | 10.2210/pdb4ehg/pdb |
Related | 4EHE |
Descriptor | Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide (2 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71356.09 |
Authors | Voegtli, W.C. (deposition date: 2012-04-02, release date: 2013-04-24, Last modification date: 2024-02-28) |
Primary citation | Mathieu, S.,Gradl, S.N.,Ren, L.,Wen, Z.,Aliagas, I.,Gunzner-Toste, J.,Lee, W.,Pulk, R.,Zhao, G.,Alicke, B.,Boggs, J.W.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Gloor, S.L.,Gould, S.E.,Hansen, J.D.,Hastings, G.,Hatzivassiliou, G.,Laird, E.R.,Moreno, D.,Ran, Y.,Voegtli, W.C.,Wenglowsky, S.,Grina, J.,Rudolph, J. Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties. J.Med.Chem., 55:2869-2881, 2012 Cited by PubMed: 22335519DOI: 10.1021/jm300016v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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